THEME 1.0 NUTRA-SCIENZA- WORKSHOP 2013
Strategies for establishing a Healthy Gut Microbiome by : PAOLO MANZELLI firstname.lastname@example.org
Emerging knowledge on the human microbiome within the intestinal tract is opening up vast new horizons in our understanding factors influencing diet related diseases as metabolic syndrome, obesity and other comorbidities and brain imparments in the regulation of brain development and behaviour.
A healthy gut microbiome is, essentially, a biochemical organ performing many metabolic and absorption nutritional functions, produces some vitamins and antigens, thus regulates innate and acquired immunity through modulating signaling that affect and circadian rhythms of some body’s and mental functions.
To define the best strategies getting a healthy gut microbiome a key aspect of the FUHONU project is to understand how epigenetic factors as diet, physical activity and lifestyle, are affecting changes of microbiome/genome symbiosis modulation.
The four years of FUHONU program and activities (1) would deeply prove potential links between the human microbiota and human health, and to construct innovation- strategies for manipulating the and reshaping gut microbiome on the basis of an long-term epidemological study and preclinical trials by using appropriated diets composed with high quality food, functional foods, pro-and pre-biotics and nutraceitics, in order to open new approches for the prevention of metabolic and immune diseases.
By subsequent work programs the FUNONU research would favor a deeper analysis in microbiome genetics and metabolomics to become clearer how the complex links between modulation of the microbiome can prevent the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes,
Furthermore a specific work program will be dedicated to understand how some types of diets prevent mental-health in fact is well known that for instance he gut inflammation compromises brain and behavior l provoking imparments such as stress, depression or anxiety. Hence the FUHONU project would discover how dietary and lifestyle modifications to improve gut-brain function.
In conclusion FUHONU European KBBE project mainly expects to have a high impact to favor appropriated dietary strategies to enhance an “healthy gut microbiome” and by disseminating a broad range of information to prevent health for having as ultimate goal an active population and to advance in HORIZON 2020 priority’s on food quality production for a better and sustainable social life.
(1)- FUHONU PROJECT STRUCTURE : http://gsjournal.net/Science-Journals/Essays-Biology%20/%20Medicine/Download/4474
PAOLO MANZELLI Director of LRE/EGO-CreaNet – University of Florence
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